Asymmetric synthesis of organoelemental analogs of natural compounds. 7. (2R,3S)-2-amino-3-hydroxy-5-phosphonovaleric acid
β Scribed by V. A. Soloshonok; N. Yu. Svistunova; V. P. Kukhar'; A. O. Gudima; N. A. Kuz'mina; Yu. N. Belokon'
- Book ID
- 112424252
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 253 KB
- Volume
- 41
- Category
- Article
- ISSN
- 1573-9171
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π SIMILAR VOLUMES
The first asymmetric synthesis of (2S)-, and (2R)-amino-3,3-dimethoxypropanoic acid (a-formylglycine dimethylacetal) has been achieved in two steps and 91% overall yield. The key step involved the quenching of a chiral glycine titanium enolate with trimethyl orthoformate.
2S,3S,4R)-4-Amino-3-hydroxy-2-methylpentanoic acid has been synthesized through acylation of a chiral enolate and subsequent stereoselective reduction.
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
3-Amino-2-hydroxydecanoic acid (AHDA) is a novel amino acid which has been suggested as the Nterminal component of the recently isolated angiotensin-converting "enzyme inhibitor microginin. The naturally occurring amino acid was found to possess syn relative stereochemistry and (2S,3R) absolute ster