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The first asymmetric synthesis of (2S)- and (2R)-amino-3,3-dimethoxypropanoic acid

✍ Scribed by Duane E. DeMong; Robert M. Williams

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 126 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00269-1

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✦ Synopsis

The first asymmetric synthesis of (2S)-, and (2R)-amino-3,3-dimethoxypropanoic acid (a-formylglycine dimethylacetal) has been achieved in two steps and 91% overall yield. The key step involved the quenching of a chiral glycine titanium enolate with trimethyl orthoformate.

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