Asymmetric synthesis of heteroorganic analogs of natural compounds. XVI. Asymmetric synthesis and study of the specific bioactivity of (2R,3S)- and (2S,3R)-2-amino-3-hydroxy-4-phosphonobutyric acids
β Scribed by V. A. Soloshonok; N. Yu. Svistunova; R. N. Skryma; V. V. Rybal'chenko; V. P. Kukhar; A. I. Luik; Yu. N. Belokon; N. A. Kuz'mina
- Book ID
- 112408765
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 287 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0091-150X
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π SIMILAR VOLUMES
The first asymmetric synthesis of (2S)-, and (2R)-amino-3,3-dimethoxypropanoic acid (a-formylglycine dimethylacetal) has been achieved in two steps and 91% overall yield. The key step involved the quenching of a chiral glycine titanium enolate with trimethyl orthoformate.
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