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Asymmetric synthesis of heteroorganic analogs of natural compounds. XVI. Asymmetric synthesis and study of the specific bioactivity of (2R,3S)- and (2S,3R)-2-amino-3-hydroxy-4-phosphonobutyric acids

✍ Scribed by V. A. Soloshonok; N. Yu. Svistunova; R. N. Skryma; V. V. Rybal'chenko; V. P. Kukhar; A. I. Luik; Yu. N. Belokon; N. A. Kuz'mina


Book ID
112408765
Publisher
Springer
Year
1993
Tongue
English
Weight
287 KB
Volume
27
Category
Article
ISSN
0091-150X

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The first asymmetric synthesis of (2S)-
✍ Duane E. DeMong; Robert M. Williams πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 126 KB

The first asymmetric synthesis of (2S)-, and (2R)-amino-3,3-dimethoxypropanoic acid (a-formylglycine dimethylacetal) has been achieved in two steps and 91% overall yield. The key step involved the quenching of a chiral glycine titanium enolate with trimethyl orthoformate.

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