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Asymmetric Induction of Three Consecutive Chiral Centers by Reactions of N-Enoylthioamides with Aldehydes.

✍ Scribed by Tadashi Kataoka; Hironori Kinoshita; Sayaka Kinoshita; Takashi Osamura; Shinichi Watanabe; Tatsunori Iwamura; Osamu Muraoka; Genzoh Tanabe


Publisher
John Wiley and Sons
Year
2003
Weight
139 KB
Volume
34
Category
Article
ISSN
0931-7597

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Asymmetric Synthesis of Ξ²-Hydroxy Esters Having Three Consecutive Chiral Centers with a Reductase from Bakers' Yeast. -The title reaction is investigated with Ξ²-keto esters (I) having a secondary alkyl group at the Ξ±-position. The corresponding Ξ²-hydroxy esters can be isolated in excellent enantios