Asymmetric Induction of Three Consecutive Chiral Centers by Reactions of N-Enoylthioamides with Aldehydes
β Scribed by Tadashi Kataoka; Hironori Kinoshita; Sayaka Kinoshita; Takashi Osamura; Shin-ichi Watanabe; Tatsunori Iwamura; Osamu Muraoka; Genzoh Tanabe
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 117 KB
- Volume
- 115
- Category
- Article
- ISSN
- 0044-8249
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Asymmetric Synthesis of Ξ²-Hydroxy Esters Having Three Consecutive Chiral Centers with a Reductase from Bakers' Yeast. -The title reaction is investigated with Ξ²-keto esters (I) having a secondary alkyl group at the Ξ±-position. The corresponding Ξ²-hydroxy esters can be isolated in excellent enantios