Asymmetric glycine enolate aldol reactions: synthesis of cyclosporin's unusual amino acid, MeBmt

Total synthesis of the unusual cyclospor

Total synthesis of the unusual cyclosporine amino acid MeBMT

✍ Roger D Tung; Daniel H Rich 📂 Article 📅 1987 🏛 Elsevier Science 🌐 French ⚖ 269 KB

Application of the gold(I)-Catalyzed ald

Application of the gold(I)-Catalyzed aldol reaction to a stereoselective synthesis of (2S, 3R, 4R, 6E)-3-Hydroxy-4-methyl-2-(methylamino)oct-6-enoic Acid ( = MeBmt), Cyclosporin's unusual amino acid

✍ Antonio Togni; Stephen D. Pastor; Grety Rihs 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 German ⚖ 507 KB

Introduction. ~ Stereoselective C-C bond forming reactions catalyzed by chiral transition-metal complexes are a topic of fundamental importance [l]. In 1986, Hayashi and Zto reported an elegant asymmetric synthesis of dihydrooxazoles by an efficient gold(1)-catalyzed coupling of aldehydes with 2-iso

Catalytic Asymmetric Synthesis of β-Hydr

Catalytic Asymmetric Synthesis of β-Hydroxy-α-amino Acid Esters by Direct Aldol Reaction of Glycinate Schiff Bases.

✍ Naoki Yoshikawa; Masakatsu Shibasaki 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 230 KB 👁 1 views

A Short Synthesis of Azasugars via Aldol

A Short Synthesis of Azasugars via Aldol Reaction of Chelated Amino Acid Ester Enolates

✍ Roland Grandel; Uli Kazmaier 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 528 KB

Aldol reaetionsof chelatedamino acid esterenolateswith chiral aldehydesgives rise to polyhydroxylated aminoacidain a highlystereoaelective fmhion.Theaeoxygenated aminoacidscanbe convertedinto polyhydroxylatedpipecolinicacids and azaaugarsby cyclizationusingthe Mitaunobu reaction.A interesting epimer

Catalytic Enantio- and Diastereoselectiv

Catalytic Enantio- and Diastereoselective Aldol Reactions of Glycine-Derived Silicon Enolate with Aldehydes: An Efficient Approach to the Asymmetric Synthesis of anti-β-Hydroxy-α-Amino Acid Derivatives.

✍ Jun Kobayashi; Masayuki Nakamura; Yuichiro Mori; Yasuhiro Yamashita; Shu Kobayas 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 28 KB 👁 3 views

Catalytic Enantio- and Diastereoselectiv

Catalytic Enantio- and Diastereoselective Aldol Reactions of Glycine-Derived Silicon Enolate with Aldehydes: An Efficient Approach to the Asymmetric Synthesis of anti -β-Hydroxy-α-Amino Acid Derivatives

✍ Kobayashi, Jun; Nakamura, Masayuki; Mori, Yuichiro; Yamashita, Yasuhiro; Kobayas 📂 Article 📅 2004 🏛 American Chemical Society 🌐 English ⚖ 47 KB