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Total synthesis of the unusual cyclosporine amino acid MeBMT

✍ Scribed by Roger D Tung; Daniel H Rich


Book ID
108382711
Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
269 KB
Volume
28
Category
Article
ISSN
0040-4039

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## Abstract For Abstract see ChemInform Abstract in Full Text.

Formal synthesis of an unusual amino aci
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A syn-(2R)-amino-l,3,4-butanetriol derivative, readily available from Disoascorbic acid, was utilized for the synthesis of MeBmt found in the immunosuppressive undecacyclopeptide cyclosporin. This new strategy involves diastereoselective nucleophilic 1,4-addition of lithium dimethylcuprate to a chir