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Catalytic Enantio- and Diastereoselective Aldol Reactions of Glycine-Derived Silicon Enolate with Aldehydes: An Efficient Approach to the Asymmetric Synthesis of anti -β-Hydroxy-α-Amino Acid Derivatives

✍ Scribed by Kobayashi, Jun; Nakamura, Masayuki; Mori, Yuichiro; Yamashita, Yasuhiro; Kobayashi, Shū


Book ID
119958919
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
47 KB
Volume
126
Category
Article
ISSN
0002-7863

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Efficient Synthesis of β-Hydroxy-α-Amino
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## Abstract An easily available and efficient chiral __N__,__N__′‐dioxide–nickel(II) complex catalyst has been developed for the direct catalytic asymmetric aldol reaction of α‐isothiocyanato imide with aldehydes which produces the products in morderate to high yields (up to 98 %) with excellent di