Asymmetric allylation of aldehydes catalyzed by substoichiometric amounts of chiral phosphoramides
โ Scribed by Katsuhiko Iseki; Yoshichika Kuroki; Mie Takahashi; Yoshiro Kobayashi
- Book ID
- 103409469
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 137 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
Chiral phosphoramides prepared from (S)-proline were used to catalyze the allylation and crotylation of aromatic aldehydes with allylic trichlorosilanes in good enantioseleetive yields. Phosphoramides 4d and 4m gave chiral homoallylic alcohols and their enantiomers, respectively, with similar levels
Allylation of aldehydes with allyltrichlorosilane in the presence of sulfoxides is reported. The use of excess of (R)-methyl-p-tolylsulfoxide resulted in the formation of the corresponding homoallylic alcohols in good yields and moderate enantiomeric excesses.