Asymetric synthesis of 11C-labelled amino acids
✍ Scribed by K.J. Fastch; G. Antoni; P. Malmborg; B. Långström
- Publisher
- Elsevier Science
- Year
- 1988
- Weight
- 71 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0883-2889
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## Abstract An efficient approach to the enantioselective synthesis of a series of amino acids from either bromoacetyl bromide or glycine is described using a [2,3]‐sigmatropic rearrangement to establish the stereogenic centre at C‐2 under mild conditions. Protected allylglycine **5** is a valuable
## Abstract We report the synthesis of ^11^C‐labelled choline using the reaction of “nocarrier‐added” ^11^C‐labelled methyliodide and 2‐amino‐(N,N‐dimethyl)‐ethanol. After determining the optimum temperature and duration for the reaction, we achieved a radiochemical yield of about 30% and the radio