𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Astrocytes Increase the Functional Expression of P-Glycoprotein in an In Vitro Model of The Blood-Brain Barrier

✍ Scribed by Pieter Jaap Gaillard; Inez Cornelia Johanna van der Sandt; Levina Helena Voorwinden; Dung Vu; Jette Lyngholm Nielsen; Albertus Gerrit de Boer; Douwe Durk Breimer


Book ID
111561537
Publisher
Springer US
Year
2000
Tongue
English
Weight
278 KB
Volume
17
Category
Article
ISSN
0724-8741

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Pharmacokinetics of P-glycoprotein inhib
✍ Stina SyvΓ€nen; Andrew Hooker; Obaidur Rahman; Helena Wilking; Gunnar Blomquist; πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 338 KB

This article describes the experimental set-up and pharmacokinetic modeling of P-glycoprotein function in the rat blood-brain barrier using [ 11 C]verapamil as the substrate and cyclosporin A as an inhibitor of P-gp. [ 11 C]verapamil was administered to rats as an i.v. bolus dose followed by graded

Enhanced cerebral uptake of receptor lig
✍ P. Doze; A. Van Waarde; P.H. Elsinga; N.H. Hendrikse;; W. Vaalburg πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 170 KB πŸ‘ 2 views

Low cerebral uptake of some therapeutic drugs can be enhanced by modulation of P-glycoprotein (P-gp), an ATP-driven drug efflux pump at the blood-brain barrier (BBB). We investigated the possibility of increasing cerebral uptake of the beta-adrenergic ligands S-1'-[(18)F]-fluorocarazolol (FCAR) and