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Association between presenilin 1 intronic polymorphism and late onset Alzheimer's disease in the North Chinese population

โœ Scribed by Longfei Jia; Chunkui Zhou; Haiyan Lv; Weishan Wang; Jing Ye; Xiaojun Zhang; Weidong Zhou; Jiangtao Xu; Lingling Wang; Jianping Jia

Book ID
113502104
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
171 KB
Volume
1116
Category
Article
ISSN
0006-8993

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Mutations in the Presenilin 1 (PS1) gene on chromosome 14 cause most early-onset familial Alzheimer's disease (AD). An intronic polymorphism in the PS1 gene was recently identified and reported to be associated with late-onset AD [Wragg et al., Lancet 347: 509-512, 1996]. The authors found an excess

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Recent reports have shown an association between an intronic polymorphism of the presenilin-1 (PSEN1) gene and late-onset (age at onset > 65) familial and sporadic (no family history) Alzheimer disease (AD). The reported association was independent of the effect of the only previously identified gen