Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene in schizophrenia
β Scribed by Qing-he Xing; Sheng-nan Wu; Zhi-guang Lin; Hua-fang Li; Jian-dong Yang; Guo-yin Feng; Ming-tai Wang; Wei-wei Yang; Lin He
- Book ID
- 119555097
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 109 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0920-9964
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The dopamine D4 receptor (DRD4) is a member of the D2-like dopamine receptor family. Polymorphisms at the DRD4 gene have been examined for association with a wide range of neuropsychiatric disorders and normal behavioral variation. The DRD4 gene is unusual in its high amount of expressed polymorphis
## Abstract Alterations in dopaminergic system have been implicated in the pathophysiology of this disease for many years, and this study was performed to assess the possible involvement of the dopamine D4 receptor (__DRD4__) gene polymorphisms either in the 5β² upstream or in the coding regions, in