Association study of polymorphisms in the 5′ upstream region of human DISC1 gene with schizophrenia
✍ Scribed by Thessa T.J.P. Kockelkorn; Makoto Arai; Hiroyuki Matsumoto; Norishige Fukuda; Kazuo Yamada; Yoshio Minabe; Tomoko Toyota; Hiroshi Ujike; Ichiro Sora; Norio Mori; Takeo Yoshikawa; Masanari Itokawa
- Book ID
- 116766952
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 109 KB
- Volume
- 368
- Category
- Article
- ISSN
- 0304-3940
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Possible involvement of receptors in the pathogenesis of schizophrenia has been suggested. In this study we searched systematically for polymorphisms in the 5-franking region of the 1 receptor. Genetic variation in this region could reduce the expression of the gene, and this suggestion is compatibl
## Abstract The tetrapeptide of cholecystokinin (CCK), CCK‐4, is known to induce panic attacks in human subjects, while CCK‐8 is reported to have a therapeutic effect on schizophrenia symptoms. Recently, we have identified a novel microsatellite polymorphism in the 5′ upstream region of the CCK gen