Association analysis between K and −116A variants of butyrylcholinesterase and Alzheimer’s disease in a Brazilian population
✍ Scribed by Simão-Silva, Daiane Priscila; Bertolucci, Paulo Henrique Ferreira; de Labio, Roger William; Payão, Spencer Luiz Marques; Furtado-Alle, Lupe; Souza, Ricardo Lehtonen Rodrigues
- Book ID
- 123342055
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 163 KB
- Volume
- 203
- Category
- Article
- ISSN
- 0009-2797
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Increased butyrylcholinesterase (BChE) activity has been reported to be associated with the formation of amyloid plaques and neurofibrillary tangles and may consequently be involved in the pathogenesis of Alzheimer disease (AD). Because the catalytic activity of BChE-K variant is reduced by one-thir
Butyrylcholinesterase (BChE) as well as acetylcholinesterase has been suggested to be associated with Alzheimer's disease (AD). : Hum Mol Genet 6: 1933-1936] recently reported the synergism between the gene for the K variant of BChE (BCHE-K) and the 4 allele of apolipoprotein E (APOE 4) in late-onse