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Analysis of association between butyrylcholinesterase K variant and apolipoprotein E genotypes in Alzheimer's disease

✍ Scribed by Asad Vaisi Raygani; Mahine Zahrai; Akbar Soltanzadeh; Mahmood Doosti; Ebrahim Javadi; Tayebeh Pourmotabbed

Book ID
116767134
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
77 KB
Volume
371
Category
Article
ISSN
0304-3940

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Butyrylcholinesterase (BChE) as well as acetylcholinesterase has been suggested to be associated with Alzheimer's disease (AD). : Hum Mol Genet 6: 1933-1936] recently reported the synergism between the gene for the K variant of BChE (BCHE-K) and the 4 allele of apolipoprotein E (APOE 4) in late-onse

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Increased butyrylcholinesterase (BChE) activity has been reported to be associated with the formation of amyloid plaques and neurofibrillary tangles and may consequently be involved in the pathogenesis of Alzheimer disease (AD). Because the catalytic activity of BChE-K variant is reduced by one-thir