Increased butyrylcholinesterase (BChE) activity has been reported to be associated with the formation of amyloid plaques and neurofibrillary tangles and may consequently be involved in the pathogenesis of Alzheimer disease (AD). Because the catalytic activity of BChE-K variant is reduced by one-thir
β¦ LIBER β¦
Analysis of association between Alzheimer disease and the K variant of butyrylcholinesterase (BCHE-K)
β Scribed by Janet M. Grubber; Ann M. Saunders; Alison R. Crane-Gatherum; William K. Scott; Eden R. Martin; Carol S. Haynes; P.M. Conneally; Gary W. Small; Allen D. Roses; Jonathan L. Haines; Margaret A. Pericak-Vance
- Book ID
- 117477808
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 90 KB
- Volume
- 269
- Category
- Article
- ISSN
- 0304-3940
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Butyrylcholinesterase (BChE) as well as acetylcholinesterase has been suggested to be associated with Alzheimer's disease (AD). : Hum Mol Genet 6: 1933-1936] recently reported the synergism between the gene for the K variant of BChE (BCHE-K) and the 4 allele of apolipoprotein E (APOE 4) in late-onse