Increased butyrylcholinesterase (BChE) activity has been reported to be associated with the formation of amyloid plaques and neurofibrillary tangles and may consequently be involved in the pathogenesis of Alzheimer disease (AD). Because the catalytic activity of BChE-K variant is reduced by one-thir
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Age-dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brains
โ Scribed by Estifanos Ghebremedhin; Dietmar R Thal; Christian Schultz; Heiko Braak
- Book ID
- 117472488
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 137 KB
- Volume
- 320
- Category
- Article
- ISSN
- 0304-3940
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Butyrylcholinesterase (BChE) as well as acetylcholinesterase has been suggested to be associated with Alzheimer's disease (AD). : Hum Mol Genet 6: 1933-1936] recently reported the synergism between the gene for the K variant of BChE (BCHE-K) and the 4 allele of apolipoprotein E (APOE 4) in late-onse