No association between apolipoprotein E genotype and late-onset depression in Alzheimer's disease
β Scribed by Marc Cantillon; Dylan Harwood; Warren Barker; Peter St. George-Hyslop; Takehide Tsuda; Rogaeva Ekatarina; Ranjan Duara
- Book ID
- 118510949
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 242 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0006-3223
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Butyrylcholinesterase (BChE) as well as acetylcholinesterase has been suggested to be associated with Alzheimer's disease (AD). : Hum Mol Genet 6: 1933-1936] recently reported the synergism between the gene for the K variant of BChE (BCHE-K) and the 4 allele of apolipoprotein E (APOE 4) in late-onse
## Abstract The effect of the apolipoprotein E (APOE) Ο΅4 allele on age of onset was analyzed in two groups of families with earlyβonset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) earlyβonset nonβVG families showing evidence of linkage