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Assignment of the dipeptidylpeptidase IV (DPP4) gene to pig Chromosome 15q21

✍ Scribed by Preben D. Thomsen; Hanne Qvist; Lena Marklund; Leif Andersson; Hans Sjöström; Ove Norén

Publisher
Springer-Verlag
Year
1993
Tongue
English
Weight
590 KB
Volume
4
Category
Article
ISSN
0938-8990

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✦ Synopsis

A porcine 2-kb partial dipeptidylpeptidase IV (DPP4, EC 3.4.i4.5) cDNA clone and a porcine 16-kb genomic fragment containing parts of the DPP4 gene were isolated, characterized, and used as probes to map the DPP4 gene to pig Chr (Chr) 15q21 by fluorescence in situ hybridization. A two-allele RFLP was revealed for the DPP4 gene. This polymorphism was utilized in a linkage test against the erythrocyte antigen G (EAG), previously assigned to Chr 15, and the microsatellite S0088, which is linked to EAG. The linkage analyses revealed significant evidence for linkage confirming the assignment of DPP4 to Chr 15.

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