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Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25

✍ Scribed by Olaf Riess; Cornelia Epplen; Ina Siedlaczck; Jörg T. Epplen

Publisher
Springer
Year
1993
Tongue
English
Weight
222 KB
Volume
92
Category
Article
ISSN
0340-6717

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✦ Synopsis

The 3'-end of the cDNA encoding the smg GDP dissociation stimulator (smg GDS) protein shares 100% homology with the previously published expressed sequence tag 00038 site. This site extends the 3'-end of the smg GDS gene by 212 bp. It has been localized to human chromosome 4. Here, we have refined the localization of smg GDP to human chromosome 4q21-q25 using a mapping panel of rodent/human somatic cell hybrids containing different parts of chromosome 4. This chromosomal localization of smg GDP to 4q21-25 overlaps with a region of allele loss in primary hepatocellular carcinoma (4q13-q26).

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