𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization

✍ Scribed by J. T. Elder; A. Åström; U. Pettersson; J. J. Voorhees; J. M. Trent

Publisher
Springer
Year
1992
Tongue
English
Weight
483 KB
Volume
89
Category
Article
ISSN
0340-6717

No coin nor oath required. For personal study only.

✦ Synopsis

Two highly conserved forms of cellular retinoic acid binding protein (CRABP-I and CRABP-II) have been described, and one, CRABP-II, is highly expressed in human skin. We have utilized a 10-kb fragment containing the human CRABP-II (hCRABP-II) gene (isolated from a human genomic library) to localize hCRABP-II to human chromosome 1 band q21 by fluorescence in situ hybridization. Localization to 1q was confirmed by hybridization of a hCRABP-II cDNA clone against a human-mouse hybrid cell line containing a t(1;6)(q21;q13)) translocation chromosome. The hCRABP-II gene is therefore localized to a band known to contain several other genes that are expressed in the context of epidermal differentiation, including profilaggrin, loricrin, involucrin, and calcyclin.

📜 SIMILAR VOLUMES

Mapping of the ribophorin II (RPN II) ge
Mapping of the ribophorin II (RPN II) gene to human chromosome 20q12–q13.1 by in-situ hybridization
✍ Christiane Löffler; V. V. N. Gopal Rao; Ingo Hansmann 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 187 KB

Ribophorin I and II (RPN I and RPN II), two specific glycoproteins, span the rough regions of the endoplasmic reticulum (RER) and are thought to play an important role either in translocation or in the maintenance of RER. Studies with human-mouse somatic cell hybrids have localized the gene for RPN