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Assessment of hepatic portal perfusion using T2* measurements of Gd-DTPA

✍ Scribed by Hidemasa Uematsu; Hiroki Yamada; Norihiro Sadato; Satoshi Muramoto; Hiroshi Inoue; Koji Hayashi; Yoshiharu Yonekura; Hirohiko Kimura; Hajime Sakuma; Tetsuya Matsuda; Nobushige Hayashi; Kazutaka Yamamoto; Yasushi Ishii

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
526 KB
Volume
8
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

Recently, perfusion imaging has been of increasing interest in MRI. We applied this method for semiquantitative evaluation of hepatic parenchymal portal blood flow in patients with diffuse liver damage. Twenty patients with diffuse hepatic damage were divided according to the Child's Classification and studied. Gadolinium‐diethylenetriamine pentaacetic acid (Gd‐DTPA) was administered into the superior mesenteric artery (SMA), and a dynamic series of T2*‐weighted fast low angle shot (FLASH) images was obtained. We evaluated relative regional portal blood volume (rrPBV), mean transit time (MTT), and relative regional portal blood flow (rrPBF). The relationship between the rrPBV, rrPBF, and plasma indocyanine green retention rate test at 15 minutes (ICGR~15~) was also evaluated in 12 patients. Both rrPBF and rrPBV are significantly decreased in Child B & C patients compared with Child A patients. On the other hand, the MTT is significantly prolonged in Child B & C patients compared with Child A patients. Significant correlations were also noted between rrPBV and ICGR~15~ and between rrPBF and ICGR~15~. By means of selective catheterization into the SMA, we were able to estimate rrPBV, rrPBF, and MTT. This method may play a clinical role for assessment of regional portal perfusion in various diseases with diffuse liver damage.

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