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Arylpiperazine derivatives as high-affinity 5-HT1A serotonin ligands

โœ Scribed by Glennon, Richard A.; Naiman, Noreen A.; Lyon, Robert A.; Titeler, Milt

Book ID
127182060
Publisher
American Chemical Society
Year
1988
Tongue
English
Weight
528 KB
Volume
31
Category
Article
ISSN
0022-2623

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The synthesis and evaluation as 5-HT 1A and 5-HT 7 serotonin receptor ligands of the two sets of O-substituted hydroxybenzamides, structurally related to 2-{3-[4-(2-methoxyphenyl)piperazin-1-yl]pro-poxy}benzamide (1), (K i 5-HT 1A ยผ 21 nM, 5-HT 7 ยผ 234 nM) are reported. To affect the affinity for 5-