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Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors

✍ Scribed by Marcello Leopoldo; Francesco Berardi; Nicola A. Colabufo; Marialessandra Contino; Enza Lacivita; Roberto Perrone; Vincenzo Tortorella


Book ID
111769040
Publisher
Pharmaceutical Press
Year
2004
Tongue
English
Weight
335 KB
Volume
56
Category
Article
ISSN
2042-7158

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Evaluation of 1-arylpiperazine derivativ
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The synthesis and evaluation as 5-HT 1A and 5-HT 7 serotonin receptor ligands of the two sets of O-substituted hydroxybenzamides, structurally related to 2-{3-[4-(2-methoxyphenyl)piperazin-1-yl]pro-poxy}benzamide (1), (K i 5-HT 1A ΒΌ 21 nM, 5-HT 7 ΒΌ 234 nM) are reported. To affect the affinity for 5-