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New Arylpiperazines with Flexible versus Partly Constrained Linker as Serotonin 5-HT 1A /5-HT 7 Receptor Ligands

✍ Scribed by Kowalski, Piotr; Mitka, Katarzyna; Jaśkowska, Jolanta; Duszyńska, Beata; Bojarski, Andrzej J.


Book ID
126701363
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
244 KB
Volume
346
Category
Article
ISSN
0365-6233

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The synthesis and evaluation as 5-HT 1A and 5-HT 7 serotonin receptor ligands of the two sets of O-substituted hydroxybenzamides, structurally related to 2-{3-[4-(2-methoxyphenyl)piperazin-1-yl]pro-poxy}benzamide (1), (K i 5-HT 1A ¼ 21 nM, 5-HT 7 ¼ 234 nM) are reported. To affect the affinity for 5-