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Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D3 and Serotonin 5-HT1A and 5-HT2A Receptors

✍ Scribed by Butini, Stefania; Campiani, Giuseppe; Franceschini, Silvia; Trotta, Francesco; Kumar, Vinod; Guarino, Egeria; Borrelli, Giuseppe; Fiorini, Isabella; Novellino, Ettore; Fattorusso, Caterina

Book ID: 111987741
Publisher: American Chemical Society
Year: 2010
Tongue: English
Weight: 797 KB
Volume: 53
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm100294b

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The synthesis and evaluation as 5-HT 1A and 5-HT 7 serotonin receptor ligands of the two sets of O-substituted hydroxybenzamides, structurally related to 2-{3-[4-(2-methoxyphenyl)piperazin-1-yl]pro-poxy}benzamide (1), (K i 5-HT 1A ¼ 21 nM, 5-HT 7 ¼ 234 nM) are reported. To affect the affinity for 5-