Design and Synthesis of New Benzimidazole-Arylpiperazine Derivatives Acting as Mixed 5-HT1A/5-HT3 Ligands.
β Scribed by Maria L. Lopez-Rodriguez; Bellinda Benhamu; Ma. Jose Morcillo; Ignacio Tejada; David Avila; Isabel Marco; Lucio Schiapparelli; Diana Frechilla; Joaquin Del Rio
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 79 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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π SIMILAR VOLUMES
The synthesis and evaluation as 5-HT 1A and 5-HT 7 serotonin receptor ligands of the two sets of O-substituted hydroxybenzamides, structurally related to 2-{3-[4-(2-methoxyphenyl)piperazin-1-yl]pro-poxy}benzamide (1), (K i 5-HT 1A ΒΌ 21 nM, 5-HT 7 ΒΌ 234 nM) are reported. To affect the affinity for 5-
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A series of new 3-(o-aminoalkyl)-S,S-disubstituted hydantoins, containing 1 -pheny lpiperazine, 1 -(o-methoxy pheny 1)piperazine or 1,2,3,4-tetrahydroisoquinoline fragments, were synthesized by standard alkylation procedures and their 5-HTIA and 5 -m ~~ receptor affinities were determined. It has be