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Approaches to the synthesis of retro-inverso peptides

✍ Scribed by PALLAI, P.V. ;RICHMAN, S. ;STRUTHERS, R.S. ;GOODMAN, M.

Book ID
115098045
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
532 KB
Volume
21
Category
Article
ISSN
0367-8377

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Solid-phase synthesis of partially-modif
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✍ Alessandro Volonterio; Pierfrancesco Bravo; Nathalie Moussier; Matteo Zanda * πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 193 KB

The solid-phase synthesis of a novel class of retro and retro-inverso peptides featuring a 2[NHCH(CF 3 )] surrogate of the classical (NHΓ€CO) retro-peptide bond has been accomplished. Wang resin bound a-amino esters 2 were engaged in Michael-type N-additions with 3-(E-enoyl)-1,3-oxazolidin-2one 3, wh