Synthesis of ‘retro-inverso’ peptide nucleic acids: 2. Oligomerization and stability
✍ Scribed by Achim H. Krotz; Ole Buchardt; Peter E. Nielsen
- Book ID
- 103405141
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 207 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The solid-phase synthesis of a novel class of retro and retro-inverso peptides featuring a 2[NHCH(CF 3 )] surrogate of the classical (NHÀCO) retro-peptide bond has been accomplished. Wang resin bound a-amino esters 2 were engaged in Michael-type N-additions with 3-(E-enoyl)-1,3-oxazolidin-2one 3, wh
## Abstract Partially modified retro‐ (PMR) and retro‐inverso (PMRI) ψ[NHCH(CF~3~)]Gly peptides, a conceptually new class of peptidomimetics, have been synthesized in wide structural diversity and variable length by aza‐Michael reaction of enantiomerically pure α‐amino esters and peptides with enan
Peptide nucleic acids (PNA) were synthesized by a modified Merrifield method using several improvements. Activation by O-[benzotriazol-1-yl]-1,1,3,3-tetramethyluronium hexafluorophosphate in combination with in situ neutralization of the resin allowed efficient coupling of all four Boc-protected PNA