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Application of Continuous Flow Micromixing Reactor Technology for Synthesis of Benzimidazole Drugs

โœ Scribed by Reddy, Gunupati Sharathchandra; Reddy, Narra Santosh; Manudhane, Kushal; Rama Krishna, Medisetti Venkata; Ramachandra, Kopparapu Janardana Sarma; Gangula, Srinivas


Book ID
120387544
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
454 KB
Volume
17
Category
Article
ISSN
1083-6160

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## Abstract magnified image A library of 1,4โ€disubstituted 1,2,3โ€triazoles was synthesized using a copper flow reactor. Organic azides, generated __in situ__ from alkyl halides and sodium azide, were reacted with acetylenes using the copperโ€catalyzed Huisgen 1,3โ€dipolar cycloaddition. This process