The Use of Copper Flow Reactor Technology for the Continuous Synthesis of 1,4-Disubstituted 1,2,3-Triazoles

✍ Scribed by Andrew R. Bogdan; Neal W. Sach

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 276 KB
• Volume: 351
• Category: Article
• ISSN: 1615-4150
• DOI: 10.1002/adsc.200800758

✦ Synopsis

Abstract

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A library of 1,4‐disubstituted 1,2,3‐triazoles was synthesized using a copper flow reactor. Organic azides, generated in situ from alkyl halides and sodium azide, were reacted with acetylenes using the copper‐catalyzed Huisgen 1,3‐dipolar cycloaddition. This process eliminates both the handling of organic azides and the need for additional copper catalyst and permits the facile preparation of numerous triazoles in a continuous flow process.