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Application of amide-stabilized sulfur ylide reactivity to the stereodivergent synthesis of (R,S)- and (S,R)-reboxetine

✍ Scribed by David M. Aparicio; Joel L. Terán; Dino Gnecco; Alberto Galindo; Jorge R. Juárez; María L. Orea; Angel Mendoza


Book ID
108284535
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
528 KB
Volume
20
Category
Article
ISSN
0957-4166

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Enantioselective synthesis of (R)- and (
✍ Paul V. Fish; Malcolm Mackenny; Gerwyn Bish; Timothy Buxton; Russell Cave; David 📂 Article 📅 2009 🏛 Elsevier Science 🌐 French ⚖ 163 KB

The (R)-and (S)-N-Boc-morpholine-2-carboxylic acids 9 and 10 were prepared using an enantioselective synthesis employing a highly selective enzyme-catalyzed kinetic resolution of racemic n-butyl 4-benzylmorpholine-2-carboxylate (11) as the key step. Acids 9 and 10 were then converted efficiently and