✦ LIBER ✦
Enantioselective synthesis of (R)- and (S)-N-Boc-morpholine-2-carboxylic acids by enzyme-catalyzed kinetic resolution: application to the synthesis of reboxetine analogs
✍ Scribed by Paul V. Fish; Malcolm Mackenny; Gerwyn Bish; Timothy Buxton; Russell Cave; David Drouard; David Hoople; Alan Jessiman; Duncan Miller; Christelle Pasquinet; Bhairavi Patel; Keith Reeves; Thomas Ryckmans; Melanie Skerten; Florian Wakenhut
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- French
- Weight
- 163 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
The (R)-and (S)-N-Boc-morpholine-2-carboxylic acids 9 and 10 were prepared using an enantioselective synthesis employing a highly selective enzyme-catalyzed kinetic resolution of racemic n-butyl 4-benzylmorpholine-2-carboxylate (11) as the key step. Acids 9 and 10 were then converted efficiently and stereoselectively to reboxetine analogs 3 and 4.