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Apolipoprotein E ε2 does not increase risk of early-onset sporadic Alzheimer's disease

✍ Scribed by W. K. Scott; A. M. Saunders; P. C. Gaskell; P. A. Locke; J. H. Growdon; L. A. Farrer; S. A. Auerbach; A. D. Roses; J. L. Haines; Dr. M. A. Pericak-Vance

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
352 KB
Volume
42
Category
Article
ISSN
0364-5134

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✦ Synopsis

We examined the association of apolipoprotein E (ApoE) genotype and the risk of early-onset Alzheimer's disease (AD) in 209 white early-onset sporadic cases (43% male) and 303 white controls (48% male) of similar age distribution. The risk of AD was significantly increased, relative to the 313 genotype, in people with the 414, 314, and 214 genotypes, controlling for age at time of examination and sex. The 213 genotype reduced slightly the risk of AD, although the effect was not statistically significant.

We conclude, contrary to some previous reports, that the ApoE ~2 allele does not increase the risk of early-onset sporadic AD.

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✍ Ephrat Levy-Lahad; Amnon Lahad; Ellen M. Wijsman; Thomas D. Bird; Dr Gerard D. S 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 339 KB 👁 2 views

## Abstract The effect of the apolipoprotein E (APOE) ϵ4 allele on age of onset was analyzed in two groups of families with early‐onset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) early‐onset non‐VG families showing evidence of linkage