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Apolipoprotein E and early-onset familial Alzheimer disease: Lack of association and age-at-onset effect

✍ Scribed by Hillmann, Edna; Hilfiker, Sandra; Keil, Nina Maria

Book ID
124142730
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
175 KB
Volume
15
Category
Article
ISSN
0197-4580

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## Abstract The effect of the apolipoprotein E (APOE) Ο΅4 allele on age of onset was analyzed in two groups of families with early‐onset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) early‐onset non‐VG families showing evidence of linkage

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An increased frequency of the apolipoprotein E type 4 allele (APOE-4) has previously been associated with both late-onset sporadic and late-onset familial Alzheimer disease (AD) [