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Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex

✍ Scribed by Bart De Strooper

Book ID
117608597
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
65 KB
Volume
38
Category
Article
ISSN
0896-6273

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✍ Goran Periz; Mark E. Fortini 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 724 KB

## Abstract The γ‐secretase complex has emerged as an unusual membrane‐bound aspartyl protease with the ability to cleave certain substrate proteins at peptide bonds believed to be buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key biochemical ste