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APH1, PEN2, and Nicastrin increase Aβ levels and γ-secretase activity

✍ Scribed by Laura Marlow; Rosa M. Canet; Sharie J. Haugabook; John A. Hardy; Debomoy K. Lahiri; Kumar Sambamurti

Book ID
117053909
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
236 KB
Volume
305
Category
Article
ISSN
0006-291X

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## Abstract The γ‐secretase complex has emerged as an unusual membrane‐bound aspartyl protease with the ability to cleave certain substrate proteins at peptide bonds believed to be buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key biochemical ste