Functional reconstitution of Ξ³-secretase
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Goran Periz; Mark E. Fortini
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Article
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2004
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John Wiley and Sons
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English
β 724 KB
## Abstract The Ξ³βsecretase complex has emerged as an unusual membraneβbound aspartyl protease with the ability to cleave certain substrate proteins at peptide bonds believed to be buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key biochemical ste