Functional reconstitution of γ-secretase
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Goran Periz; Mark E. Fortini
📂
Article
📅
2004
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John Wiley and Sons
🌐
English
⚖ 724 KB
## Abstract The γ‐secretase complex has emerged as an unusual membrane‐bound aspartyl protease with the ability to cleave certain substrate proteins at peptide bonds believed to be buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key biochemical ste