A new series of DNA binding 5,10,15-tri(N-methyl-4-pyridiniumyl)porphyrin (TrisMPyP)-platinum(II) conjugates was synthesized, in which different spacer ligands were used for appropriate coordination to platinum(II) complexes. Compound 9b exhibited in vivo antitumor activity (T/C%, 294) superior to c
Antitumor activity of binuclear cationic complexes of platinum (II)
β Scribed by A. L. Konovalova; K. I. Yakovlev; A. I. Stetsenko; N. D. Rozhkova; G. K. Gerasimova; T. I. Ivanova; N. S. Kamaletdinov; V. P. Sinditskii
- Book ID
- 112713421
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 226 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0091-150X
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## Abstract The INDOβSCF method is used to provide electronic indices which are used as independent variables. These attempt to account for the variation in the antitumor activity and toxicity observed within a series of analogs of __cis__βdiamino dichloro platinum(II).