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Synthesis and antitumor activity of DNA binding cationic porphyrin–platinum(II) complexes

✍ Scribed by Rita Song; Yeong-Sang Kim; Chong Ock Lee; Youn Soo Sohn

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
140 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

A new series of DNA binding 5,10,15-tri(N-methyl-4-pyridiniumyl)porphyrin (TrisMPyP)-platinum(II) conjugates was synthesized, in which different spacer ligands were used for appropriate coordination to platinum(II) complexes. Compound 9b exhibited in vivo antitumor activity (T/C%, 294) superior to cisplatin (T/C%, 184) against the leukemia L1210 cell line.

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