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Synthesis and antitumor activity of aminomethyl-piperidine platinum(II) complexes

✍ Scribed by Kenji Inagaki; Kiyoyuki Tajima; Yoshinori Kidani; Tazuko Tashiro; Shigeru Tsukagoshi

Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
215 KB
Volume
37
Category
Article
ISSN
0020-1693

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✦ Synopsis

In order to examine the structureactivity relationship between the platinum complexes having a bidentate ligand as non-leaving group dichloro 2aminomethylpiperidine Pt(II), PtCla(2ampip) dichloro 3-aminomethylpiperidine Pt(II), PtCla-(3ampip), and dichloro 2aminomethylpyridine Pt(II), PtClz(2-ampy), were synthesized and tested against Leukemia L-1210 in CDFr mice. Structure of the complex of Pt(I1) with 3ampip is discussed on the basis of the data of "C nmr spectrum.

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