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Calcium Ions Do Accelerate the DNA Binding of New Antitumor-Active Platinum Aminophosphonate Complexes

✍ Scribed by Marieke J. Bloemink; Jeroen J. H. Diederen; Jaco P. Dorenbos; Robert J. Heetebrĳ; Bernhard K. Keppler; Jan Reedĳk

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 219 KB
Volume: 1999
Category: Article
ISSN: 1434-1948
DOI: 10.1002/(sici)1099-0682(199910)1999:10<1655::aid-ejic1655>3.0.co;2-5

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✦ Synopsis

The presence of Ca 2+ has a marked effect on the reaction release of the phosphonate ligand as observed by NMR is significantly accelerated by the presence of Ca 2+ , which is kinetics of platinum phosphonate complexes with d(GpG). Compounds studied are [cis-Pt(NH 3 ) 2 (bmpaa)] and [Pt(R,S-ascribed to its interaction with the phosphato groups in the ligands. dach)(ntmp)]. The formation of GG-N7,N7 chelates and the

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ChemInform Abstract: Calcium Ions Do Acc

ChemInform Abstract: Calcium Ions Do Accelerate the DNA Binding of New Antitumor-Active Platinum Aminophosphate Complexes.

✍ Marieke J. Bloemink; Jeroen J. H. Diederen; Jaco P. Dorenbos; Robert J. Heetebri 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 24 KB