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ChemInform Abstract: Calcium Ions Do Accelerate the DNA Binding of New Antitumor-Active Platinum Aminophosphate Complexes.

✍ Scribed by Marieke J. Bloemink; Jeroen J. H. Diederen; Jaco P. Dorenbos; Robert J. Heetebrij; Bernhard K. Keppler; Jan Reedijk


Publisher
John Wiley and Sons
Year
2010
Weight
24 KB
Volume
30
Category
Article
ISSN
0931-7597

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Calcium Ions Do Accelerate the DNA Bindi
✍ Marieke J. Bloemink; Jeroen J. H. Diederen; Jaco P. Dorenbos; Robert J. Heetebrij 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 219 KB

The presence of Ca 2+ has a marked effect on the reaction release of the phosphonate ligand as observed by NMR is significantly accelerated by the presence of Ca 2+ , which is kinetics of platinum phosphonate complexes with d(GpG). Compounds studied are [cis-Pt(NH 3 ) 2 (bmpaa)] and [Pt(R,S-ascribed