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Antisense Blockade of p21/WAF1 Decreases Radiation-Induced G2 Arrest in Esophageal Squamous Cell Carcinoma

โœ Scribed by David A. Rigberg; Thane A. Blinman; Frances S. Kim; Michael A. Cole; David W. McFadden


Book ID
115635751
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
84 KB
Volume
81
Category
Article
ISSN
0022-4804

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## Transforming growth factor-โค1 (TGF-โค) inhibits cell-cycle progression of many types of cells by arresting them in G 1 /S phase through inhibition of the active cyclin-Cdk complexes that lead to inhibition of Rb phosphorylation. In gastriccancer cells, SNU16, TGF-โค treatment induced enhanced exp