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Antagonists of growth hormone-releasing hormone (GH-RH) inhibit in vivo proliferation of experimental pancreatic cancers and decrease IGF-II levels in tumours

✍ Scribed by K. Szepeshazi; A.V. Schally; K. Groot; P. Armatis; F. Hebert; G. Halmos

Book ID: 117666882
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 189 KB
Volume: 36
Category: Article
ISSN: 0959-8049
DOI: 10.1016/s0959-8049(99)00230-0

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## Abstract ## BACKGROUND Antagonists of growth hormone‐releasing hormone (GH‐RH) can inhibit the proliferation of various tumors either indirectly through the suppression of the pituitary growth hormone/hepatic insulin‐like growth factor I (__IGF‐I__) axis and the lowering of serum __IGF‐I__ conc