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Inhibition of proliferation, VEGF secretion of human neuroendocrine tumor cell line NCI-H727 by an antagonist of growth hormone-releasing hormone (GH-RH) in vitro

✍ Scribed by Małgorzata Sacewicz; Hanna Ławnicka; Agnieszka Siejka; Tomasz Stępień; Roman Krupiński; Jan Komorowski; Henryk Stępień

Book ID: 116334771
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 561 KB
Volume: 268
Category: Article
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2008.03.041

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## Abstract ## BACKGROUND Antagonists of growth hormone‐releasing hormone (GH‐RH) can inhibit the proliferation of various tumors either indirectly through the suppression of the pituitary growth hormone/hepatic insulin‐like growth factor I (__IGF‐I__) axis and the lowering of serum __IGF‐I__ conc