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Annovel formamidine linker for use in solid-phase synthesis

โœ Scribed by Paul S. Furth; Michael S. Reitman; Alan F. Cook


Book ID
104257555
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
189 KB
Volume
38
Category
Article
ISSN
0040-4039

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Linkers for Solid-Phase Synthesis
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Linker design is an expanding field with an exciting future in state-of-the-art organic synthesis. Ever-increasing numbers of ambitious solution phase reactions are being adapted for solid-phase organic chemistry and to accommodate them, large numbers of sophisticated linker units have been develope

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Linker design is an expanding field with an exciting future in state-of-the-art organic synthesis. Ever-increasing numbers of ambitious solution phase reactions are being adapted for solid-phase organic chemistry and to accommodate them, large numbers of sophisticated linker units have been develope

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A range of linkers for the important amidine pharmacophore, cleavable using acid or light have been developed for use in library synthesis. The utility of these linkers is demonstrated by the solid phase synthesis of the Novartis (ex-Ciha) phase II compound CGS-25019C.