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Analysis of serum placental alkaline phosphatase activity in testicular cancer and cigarette smokers

✍ Scribed by Koshida, K. ;Stigbrand, T. ;Munck-Wikland, E. ;Hisazumi, H. ;Wahren, B.

Publisher
Springer
Year
1990
Tongue
English
Weight
610 KB
Volume
18
Category
Article
ISSN
0300-5623

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✦ Synopsis

Serum PLAP/PLAP-like enzymes are elevated in testicular cancer patients and also in heavy smokers. Such elevations were measurable with anti-PLAP polyclonal and monoclonal antibodies, and an antigenic heterogeneity was demonstrated in the circulating enzymes. Thus polyclonal antibody revealed more of tumor PLAP-like antigen while a monoclonal antibody H7 detected PLAP of smokers better. PLAP of smokers and PLAP-like enzyme of cancer (seminoma) patients showed similar characteristics with respect to glycosylation pattern, charge and hydrophobicity. By these properties they were differentiated from PLAP of placenta.

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